Mifflin is a surname. Notable people with the surname include:
- Fred Mifflin (1938–2013), retired Rear Admiral in the Canadian Forces and a former politician
- James Mifflin (1839–?), United States Navy sailor in the American Civil War
- Margot Mifflin, (born 1960), U.S. Author and professor
- Ramón Mifflin (born 1947), Peruvian footballer
- Thomas Mifflin (1744–1800), American merchant and politician from Philadelphia, Pennsylvania
- George Harrison Mifflin (1845–1921), American publisher, co-founder with Henry Oscar Houghton of Houghton Mifflin Company
See also
- Mifflin Kenedy (1818-1895), South Texas rancher and steamboat operator
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