| Combination of | |
|---|---|
| Amiloride | Potassium-sparing diuretic |
| Hydrochlorothiazide | Thiazide diuretic |
| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| CompTox Dashboard (EPA) | |
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Co-amilozide (BAN) is a non-proprietary combination of amiloride and hydrochlorothiazide. Co-amilozide is used in the treatment of hypertension and congestive heart failure with the tendency of the thiazide to cause low potassium levels (hypokalaemia) offset by the potassium-sparing effects of amiloride.
Formulation
Two strengths of co-amilozide are currently available in the UK:[1]
- 2.5 mg amiloride and 25 mg hydrochlorothiazide, BAN of Co-amilozide 2.5/25 (brand name Moduret 25)
- 5 mg amiloride and 50 mg hydrochlorothiazide, BAN of Co-amilozide 5/50 (brand name Moduretic)
In North America:
- Moduretic (U.S., Canada)
- Moduretic 5-50 (U.S., Canada)
- Novamilor (Canada)
Side effects
The most common side effect is headache (about 8% of people taking it) and nausea, loss of appetite, weakness, rash and dizziness (each about 3%).[2]
Common side effects (1/10 - 1/100) include:[2]
- General: weakness, fatigue, loss of appetite, headache, dizziness.
- Circulatory system: arrhythmia.
- Gastrointestinal: nausea, diarrhea, abdominal pain.
- Skin: exanthema, itching.
- Respiratory system: shortness of breath, cough.
- Metabolic: elevated blood sugar in diabetic patients, elevated uric acid levels in the blood.
- Musculoskeletal: pain in the limbs.
References
- ↑ British National Formulary 54 September 2007
- 1 2 the Swedish official drug catalog > Normorix Retrieved on Mars 30, 2010
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