Montepulciano is a town in the province of Siena in southern Tuscany, Italy.
Montepulciano may also refer to:
- Montepulciano (grape), a red Italian wine grape variety
- Montepulciano d'Abruzzo, a red Italian wine made from the Montepulciano grape in the Abruzzo region
- Vino Nobile di Montepulciano, a red Italian wine produced in the town of Montepulciano, Italy
See also
- Club Montepulciano, a former London nightclub
- Lago di Montepulciano, a lake in the Province of Siena, Tuscany, Italy
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