Mostyn is a surname, and may refer to:
- David Mostyn (cartoonist), British comic artist
- David Mostyn (British Army officer) (1928–2007), British Army officer
- Francis Mostyn (archbishop of Cardiff) (1860–1939), Roman Catholic prelate.
- Francis Mostyn (Vicar Apostolic of the Northern District) (1800–1847), Roman Catholic prelate.
- John Mostyn (governor) (1710–1779), British Army officer and colonial administrator
- John Mostyn (music manager)
- Matt Mostyn (born 1974), Irish-Australian rugby player
- Sir Nicholas Mostyn, High Court Judge in the Family Division
- Sir Pyers Charles Mostyn, 10th Baronet (1895–1917)
- Sir Roger Mostyn, 3rd Baronet (1673–1739), Welsh politician
- Savage Mostyn (c. 1713 – 1757), Royal Navy officer
- Thomas Mostyn (fl. 1695–1697), pirate and slave trader sailing between New York and Madagascar
- Thomas Lloyd-Mostyn (1830–1861), British politician
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