Mr. & Mrs. Smith may refer to:
- Mr. & Mrs. Smith (1941 film), an American comedy directed by Alfred Hitchcock
- Mr. & Mrs. Smith (1996 TV series), a short-lived American crime drama series airing on the CBS network in 1996
- Mr. & Mrs. Smith (2005 film), an American action-comedy film starring Brad Pitt and Angelina Jolie
- Mr. & Mrs. Smith (2024 TV series), an upcoming television series based on the 2005 film
- "Mr. & Mrs. Smith" (song), a 2012 song in the musical TV series Smash
- "Mr and Mrs Smith", a song by Stereophonics on their 2015 album Keep the Village Alive
See also
- Mr and Mrs Smith and Mr Drake, a 1984 album by Cardiacs
- Mr & Mrs (disambiguation)
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