Muhammad Sultan may refer to:
- Muhammad Sultan (1538–1610), Khan of Yarkent Khanate, 1592–1610
- Muhammad Sultan (Mughal prince) (1639–1676), a son of the Mughal Emperor Aurangzeb
- Muhammad Sultan Mirza (1365–1403), a grandson of the Central Asian conqueror Timur
- Mohammad Sultan (1926–1983), a Bangladeshi politician
- Mohammad Sultan (field hockey) (1918–1971), an Afghan field hockey player
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