Nucleobindin 2

NUCB2
Identifiers
Aliases	NUCB2, HEL-S-109, NEFA, nucleobindin 2
External IDs	OMIM: 608020 MGI: 1858179 HomoloGene: 3676 GeneCards: NUCB2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	17,349,974 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	116,139,819 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; bronchial epithelial cell; ; seminal vesicula; ; bone marrow cells; ; corpus epididymis; ; Achilles tendon; ; spongy bone; ; body of pancreas; ; cavity of mouth; ; islet of Langerhans;
	Top expressed in
	seminal vesicula; ; lacrimal gland; ; salivary gland; ; submandibular gland; ; parotid gland; ; islet of Langerhans; ; saccule; ; olfactory epithelium; ; supraoptic nucleus; ; pituitary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; calcium ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; extracellular region; cytosol; plasma membrane; Golgi apparatus; extracellular exosome; nuclear envelope; endoplasmic reticulum; membrane; nucleus; endoplasmic reticulum-Golgi intermediate compartment; extracellular space; nuclear outer membrane;
Biological process	negative regulation of appetite;
	Sources:Amigo / QuickGO
Orthologs
	4925
	53322
	ENSG00000070081
	ENSMUSG00000030659
	P80303
	P81117
NM_005013; NM_001330227; NM_001352661; NM_001352662; NM_001352663;
	NM_001352664; NM_001352665; NM_001352666; NM_001352667; NM_001352668; NM_001352669; NM_001352670; NM_001352671; NM_001352672
	NM_001130479; NM_016773; NM_001360375
NP_001317156; NP_005004; NP_001339590; NP_001339591; NP_001339592;
	NP_001339593; NP_001339594; NP_001339595; NP_001339596; NP_001339597; NP_001339598; NP_001339599; NP_001339600; NP_001339601
	NP_001123951; NP_001347304
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleobindin-2 is a protein that when found in humans is encoded by the NUCB2 gene.^[5]^[6]

Nucleobindin-2 is a calcium-binding EF-hand protein.[supplied by OMIM]^[6]

NUCB2 is protein precursor of nesfatin-1

In the study of the evolution of nervous systems, NUCB2 together with SMIM20 have been found to have deep homology across all lineages that preceded creatures with central nervous systems, bilaterians, cnidarians, ctenophores, and sponges as well as in choanoflagellates.^[7]^[8]

Interactions

NUCB2 has been shown to interact with NDN.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000070081 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030659 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, et al. (August 1994). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biological Chemistry Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.
1 2 "Entrez Gene: NUCB2 nucleobindin 2".
↑ Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.
↑ Callier V (2022-06-03). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.
↑ Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". The Journal of Biological Chemistry. 275 (41): 31674–31681. doi:10.1074/jbc.M005103200. PMID 10915798.

DeAngelis MM, Doucet JP, Drury S, Sherry ST, Robichaux MB, Den Z, et al. (July 1998). "Assembly of a high-resolution map of the Acadian Usher syndrome region and localization of the nuclear EF-hand acidic gene". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1407 (1): 84–91. doi:10.1016/s0925-4439(98)00025-8. PMID 9639681.
Kroll KA, Otte S, Hirschfeld G, Barnikol-Watanabe S, Götz H, Sternbach H, et al. (June 1999). "Heterologous overexpression of human NEFA and studies on the two EF-hand calcium-binding sites". Biochemical and Biophysical Research Communications. 260 (1): 1–8. doi:10.1006/bbrc.1999.0867. PMID 10381334.
Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". The Journal of Biological Chemistry. 275 (41): 31674–31681. doi:10.1074/jbc.M005103200. PMID 10915798.
Nesselhut J, Jurgan U, Onken E, Götz H, Barnikol HU, Hirschfeld G, et al. (December 2001). "Golgi retention of human protein NEFA is mediated by its N-terminal Leu/Ile-rich region". FEBS Letters. 509 (3): 469–475. doi:10.1016/S0014-5793(01)03187-8. PMID 11749975. S2CID 31134537.
Linē A, Stengrēvics A, Slucka Z, Li G, Jankevics E, Rees RC (June 2002). "Serological identification and expression analysis of gastric cancer-associated genes". British Journal of Cancer. 86 (11): 1824–1830. doi:10.1038/sj.bjc.6600321. PMC 2375403. PMID 12087473.
Breuza L, Halbeisen R, Jenö P, Otte S, Barlowe C, Hong W, Hauri HP (November 2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46". The Journal of Biological Chemistry. 279 (45): 47242–47253. doi:10.1074/jbc.M406644200. PMID 15308636.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Islam A, Adamik B, Hawari FI, Ma G, Rouhani FN, Zhang J, Levine SJ (March 2006). "Extracellular TNFR1 release requires the calcium-dependent formation of a nucleobindin 2-ARTS-1 complex". The Journal of Biological Chemistry. 281 (10): 6860–6873. doi:10.1074/jbc.M509397200. PMID 16407280.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000070081 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030659 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7811391-5] Barnikol-Watanabe S, Gross NA, Götz H, Henkel T, Karabinos A, Kratzin H, et al. (August 1994). "Human protein NEFA, a novel DNA binding/EF-hand/leucine zipper protein. Molecular cloning and sequence analysis of the cDNA, isolation and characterization of the protein". Biological Chemistry Hoppe-Seyler. 375 (8): 497–512. doi:10.1515/bchm3.1994.375.8.497. PMID 7811391.

[entrez-6] 1 2 "Entrez Gene: NUCB2 nucleobindin 2".

[7] Yañez-Guerra LA, Thiel D, Jékely G (April 2022). O'Connell M (ed.). "Premetazoan Origin of Neuropeptide Signaling". Molecular Biology and Evolution. 39 (4): msac051. doi:10.1093/molbev/msac051. PMC 9004410. PMID 35277960.

[8] Callier V (2022-06-03). "Brain-Signal Proteins Evolved Before Animals Did". Quanta Magazine. Retrieved 2022-06-03.

[pmid10915798-9] Taniguchi N, Taniura H, Niinobe M, Takayama C, Tominaga-Yoshino K, Ogura A, Yoshikawa K (October 2000). "The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm". The Journal of Biological Chemistry. 275 (41): 31674–31681. doi:10.1074/jbc.M005103200. PMID 10915798.

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Interactions

References

Further reading