Nikša (Cyrillic: Никша) is a masculine given name, a Bosnian/Croatian/Serbian variant of Nikola (cognate to Nicholas).

Notable people with the name include:

• Nikša Bratoš (born 1959), Bosnian musician who gained fame in former Yugoslavia, member of bands Valentino and Crvena jabuka
• Nikša Dobud (born 1985), Croatian water polo player
• Nikša Gligo (born 1946), Croatian musicologist and university professor
• Nikša Gradi or Nikola Gradić / Nicoló Gradi (1825–1894), Croatian writer, politician, and lawyer from Dubrovnik
• Nikša Kaleb (born 1973), Croatian handball player
• Nikša Petrović (born 1992), Croatian football player
• Nikša Ranjina or Nicola Ragnina (1494–1582), Croatian writer and noblemen from the Republic of Ragusa (modern-day Dubrovnik)
• Nikša Roki (born 1988), Croatian swimmer
• Nikša Skelin (born 1978), Croatian rower
• Nikša Sviličić (born 1970), Croatian scientist, writer, director and musician