POU3F3
Identifiers
AliasesPOU3F3, BRN1, OTF8, brain-1, oct-8, POU class 3 homeobox 3, SNIBFIS
External IDsOMIM: 602480 MGI: 102564 HomoloGene: 68509 GeneCards: POU3F3
Orthologs
SpeciesHumanMouse
Entrez

5455

18993

Ensembl

ENSG00000198914

ENSMUSG00000045515

UniProt

P20264

P31361

RefSeq (mRNA)

NM_006236

NM_008900

RefSeq (protein)

NP_006227

NP_032926

Location (UCSC)Chr 2: 104.85 – 104.86 MbChr 1: 42.73 – 42.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

POU class 3 homeobox 3 is a protein that in humans is encoded by the POU3F3 gene. [5]

Function

This gene encodes a POU-domain containing protein that functions as a transcription factor. The encoded protein recognizes an octamer sequence in the DNA of target genes. This protein may play a role in development of the nervous system. [provided by RefSeq, Apr 2015].

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000198914 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045515 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: POU class 3 homeobox 3". Retrieved 2018-08-13.

Further reading

  • Li W, Zheng J, Deng J, You Y, Wu H, Li N, Lu J, Zhou Y (June 2014). "Increased levels of the long intergenic non-protein coding RNA POU3F3 promote DNA methylation in esophageal squamous cell carcinoma cells". Gastroenterology. 146 (7): 1714–26.e5. doi:10.1053/j.gastro.2014.03.002. PMID 24631494.
  • Guo H, Wu L, Yang Q, Ye M, Zhu X (January 2015). "Functional linc-POU3F3 is overexpressed and contributes to tumorigenesis in glioma". Gene. 554 (1): 114–9. doi:10.1016/j.gene.2014.10.038. PMID 25445282.


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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