Pache is a surname. Notable people with this surname include:
- Claude Pache (born 1943), French rower
- Cristian Pache (born 1998), Dominican professional baseball outfielder
- François Pache (born 1932), Swiss figure skater
- Jean-Nicolas Pache (1746–1823), French politician
- Johannes Pache (1857–1897), German composer
- Joseph Pache (1861–1926), German-born composer and director
- Robert Pache (1897–1974), Swiss footballer
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