Pagonis is a surname and given name. Notable people with the name include:
- surname
- Anastasia Pagonis (born 2004), American Paralympic swimmer
- Kostas Pagonis (born 1985), Greek footballer
- Nenad Pagonis (born 1987), Serbian kickboxer
- Pidgeon Pagonis (born 1986), American intersex activist
- William Pagonis (born 1941), American Army general
- given name
- Pagonis Vakalopoulos (born 1965), Greek footballer
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