Papanikolaou or Papanicolaou (Greek: Παπανικολάου) is a Greek patronymic surname, meaning "child of Father Nikolaos", used in Greece and Cyprus.
It may refer to:
People
- Christos Papanikolaou (born 1941), Greek pole vaulter
- Dimitris Papanikolaou (born 1977), Greek basketball player
- George C. Papanicolaou (born 1943), Greek-American mathematician
- Georgios Papanikolaou (1883–1962), Greek doctor, inventor of the pap smear test
- John Paul Papanicolaou (1949–2010), Greek businessman
- Kostas Papanikolaou, Greek basketball player in the National Basketball Association
- Miltiadis Papanikolaou (born 1947), Professor of History of Arts, Aristotle University of Thessaloniki
- Nikos Papanikolaou (born 1985), Greek basketball player
Other
- Papanicolaou stain, a histological technique
- Papanicolaou test, a gynecological test
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