Patrick O'Leary may refer to:

• Patrick O'Leary (canoeist), who became the first Irish Paralympic athlete to qualify for the final of the KL3 canoeing at the 2016 Summer Paralympics
• Pat O'Leary, rugby league footballer of the 1940s and 1950s
• Patrick O'Leary (writer) (born 1952), science fiction author
• Patrick Albert O'Leary, the wartime alias of Belgian Resistance member Albert Guérisse
• Patrick O'Leary, husband to Catherine O'Leary of the Great Chicago Fire
• Patrick I. O'Leary (1888–1944), Australian poet and journalist