Pearl is a surname. Notable people with the surname include:
- Bruce Pearl (born 1960), American college basketball coach
- Daniel Pearl (1963–2002), American journalist who was kidnapped and murdered in Pakistan
- Judea Pearl (born 1936), computer scientist and philosopher
- Matthew Pearl (born 1975), American novelist
- Minnie Pearl (1912–1996), American country comedian
- Nancy Pearl (born 1945), American librarian
- Perry Diamond Pearl (born c. 1824), American politician
- Raymond Pearl (1879–1940), American biologist
See also
- Pearl (given name)
- Perle (disambiguation)
- Margolis, derived from a Hebrew term meaning pearl
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