Plasencia is a surname. Notable people with the surname include:
- Alejandro D. Plascencia (born 1991), Mexican-American Citizen
- Casto Plasencia (1846–1890), Spanish painter
- César Plasencia, American soccer player
- Jorge A. Plasencia (born 1974), American businessman
- Nestor Plasencia (born c. 1950), tobacco grower and cigar maker
- Rene Plasencia (born 1973), American politician
- Steve Plasencia (born 1956), American long-distance runner
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