Poison pill may refer to:

  • Suicide pill, a physical pill for suicide by poison
  • Poison pill amendment or wrecking amendment, an addition to a legislative bill that renders it ineffective
  • Shareholder rights plan, also called a poison pill, a subclass of anti-takeover provisions that dilutes the attacker's power
  • Poison pill (NBA), a type of player contract provision for some free agents in the National Basketball Association
  • Poison pill (NFL), a type of player contract provision for some free agents in the National Football League from 1996 to 2010
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