Polecat Creek may refer to:
- Polecat Creek (Iowa), a stream in Iowa
- Polecat Creek (Grand River), a stream in Missouri
- Polecat Creek (Wilkerson Creek), a stream in Missouri
- Polecat Creek (Deep River tributary), a stream in North Carolina
- Polecat Creek (Banister River tributary), a stream in Halifax County, Virginia
- Polecat Creek (band), a North Carolina folk band
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