Poo is the surname of:
- Ai-jen Poo (born 1974), American activist
- Fernão do Pó, 15th century Portuguese navigator and explorer also known as Fernando Poo
- Karin Sham Poo (born 1943), the first female Senior Vice President of banking in Norway
- Mu-ming Poo, American neuroscientist
- Sam Poo (died 1865), a Chinese bushranger in Australia
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