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The Quebrada de Humahuaca is a narrow mountain valley located in the province of Jujuy in northwest Argentina, 1,500 km (932 mi) North of Buenos Aires. It is about 155 km (96 mi) long, oriented north-south, bordered by the Altiplano in the west and north, by the Sub-Andean hills in the east, and by the warm valleys (Valles Templados) in the south.

The Quebrada de Humahuaca has been a UNESCO World Heritage Site since 2003.