Potosi Mine may refer to:
- Cerro Rico, near Potosí, Bolivia, famous for providing vast quantities of silver for Spain during the period of the New World Spanish Empire
- Potosi Mining District in southern Nevada, U.S., named after Potosí, Bolivia
- San Luis Potosí, a Mexican state, well known for its gold and silver mines, also named after Potosí, Bolivia
See also
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