Preobrazhensky (Russian: Преображенский) is a Russian masculine surname, its feminine counterpart is Preobrazhenskaya. It may refer to
- Alexander Preobrazhensky, Russian pedagogue
- Boris Preobrazhensky, Soviet otolaryngologist and academician, Hero of Socialist Labor
- Konstantin Preobrazhensky, writer on KGB subjects
- Mikhail Preobrazhensky, architect
- Nikolay Preobrazhensky, Soviet otolaryngologist
- Olga Preobrajenska (1871–1962), ballerina of the Russian Imperial Ballet
- Olga Preobrazhenskaya (director) (1881–1971), Russian and Soviet actress and film director
- Pavel Preobrazhensky, Russian geologist
- Sofiya Preobrazhenskaya, Russian opera singer, People's Artist of the USSR
- Vasily Khrisanfovich Preobrazhensky, Russian writer
- Vasily Petrovich Preobrazhensky, Russian writer
- Yevgeni Preobrazhensky, (1886–1937) Bolshevik and economist
- Yevgeny Nikolayevich Preobrazhensky, Soviet military leader
- Fictional characters
- Professor Preobrazhensky, surgeon, from the novel Heart of a Dog by Mikhail Bulgakov
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