Prunella may refer to:
- Prunella (bird), also known as accentors or dunnocks
- Prunella (plant), also known as self-heal
- Prunella (grape), French wine grape also known as Cinsaut
- Prunella (fairy tale), an Italian fairy tale
- Prunella (film), 1918 silent film starring Marguerite Clark
- Prunella (given name)
- Prunella (horse), a Thoroughbred racehorse and broodmare
- Bargnolino, or sometimes prunella, Italian sloe gin
- Prunella (cloth), an 18th-century worsted fabric.
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