RBMY1A1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesRBMY1A1, RBM, RBM1, RBM2, RBMY, RBMY1C, YRRM1, YRRM2, RNA binding motif protein, Y-linked, family 1, member A1, RNA binding motif protein Y-linked family 1 member A1
External IDsOMIM: 400006 HomoloGene: 121598 GeneCards: RBMY1A1
Orthologs
SpeciesHumanMouse
Entrez

5940

n/a

Ensembl

ENSG00000234414

n/a

UniProt

P0DJD3

n/a

RefSeq (mRNA)

NM_005058
NM_001320944
NM_001320945

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr Y: 21.51 – 21.55 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

RNA-binding motif protein, Y chromosome, family 1 member A1/C is a protein that in humans is encoded by the RBMY1A1 gene.[3][4][5]

This gene encodes a protein containing an RNA-binding motif in the N-terminus and four SRGY (serine, arginine, glycine, tyrosine) boxes in the C-terminus. Multiple copies of this gene are found in the AZFb azoospermia factor region of chromosome Y and the encoded protein is thought to be involved in spermatogenesis. Most copies of this locus are pseudogenes, although six highly similar copies have full-length ORFs and are considered functional. Four functional copies of this gene are found within inverted repeat IR2; two functional copies of this gene are found in palindrome P3, along with two copies of PTPN13-like, Y-linked. Alternative splicing of transcripts results in two transcript variants that encode different proteins.[5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000234414 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, et al. (Jan 1994). "A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis". Cell. 75 (7): 1287–95. doi:10.1016/0092-8674(93)90616-X. PMID 8269511. S2CID 24678568.
  4. Chai NN, Zhou H, Hernandez J, Najmabadi H, Bhasin S, Yen PH (Aug 1998). "Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene". Genomics. 49 (2): 283–9. doi:10.1006/geno.1998.5255. PMID 9598316.
  5. 1 2 "Entrez Gene: RBMY1A1 RNA binding motif protein, Y-linked, family 1, member A1".

Further reading

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