ROCK may refer to:
- Chicago, Rock Island and Pacific Railroad
- Rho-associated protein kinase, a serine/threonine-specific protein kinase
- Rollergirls of Central Kentucky, roller derby league based in Lexington, Kentucky
- R.O.C.K., a 1986 hard rock/heavy metal album by Kirka
- Robert Orin Charles Kilroy, from the Styx rock opera Kilroy Was Here, see Mr. Roboto
See also
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