RWE may refer to:
- RWE AG, German multinational energy company
- RWE Incorporated, An airport services company based in Wilmington, Delaware, USA
- Ralph Waldo Emerson (1803-1882), American lecturer, philosopher, essayist, and poet
- Rot-Weiss Essen, German association football club
- Read write execute (RWE), basic permissions of a computer file
- Real world evidence (RWE), observational data obtained outside the context of randomized controlled trials (RCTs)
- Right-wing extremism, a radical, conservative hate and terrorist movement
- Radio Wolna Europa, Polish for Radio Free Europe
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