Reno is the surname of:

• Don Reno (1927–1984), American country musician
• Ginette Reno (born 1946), French-Canadian author
• Ittie Kinney Reno (1862–1941), American novelist and social leader
• Janet Reno (1938–2016), former attorney general of the United States
• Jean Reno (born 1948), French actor
• Jesse L. Reno (1823–1862), American military general during the Mexican–American War, and the American Civil War
• Jesse W. Reno (1861–1947), American inventor of the escalator
• Marcus Reno (1834–1889), American cavalry officer, participated in the Battle of Little Big Horn
• Mike Reno (born 1955), Canadian rock musician
• Tony Reno (born 1963), Swedish rock musician
• Walter E. Reno (1881–1917), American naval officer
• Franklin (Frank), John, Simeon (Sim) and William (Bill) Reno, members of the Reno Gang (died 1868), an American Civil War criminal gang
• Reno (comedian), American stand-up comedian born Karen Reno in 1956