Caitlin Sweeney bombs Community General in the last episode, and a number of characters are trapped in the rubble. Mark works hard to save Amanda's life. After 4 months pass, the hospital starts to reopen, and Steve announces that Caitlin has started robbing banks to raise money for R.O.A.R.: Revolutionary Order for Armed Rebellion. Steve and Jesse discuss plans to buy Barbecue Bob's, which is going out of business. Steve and Jesse ask Mark for a loan to buy Barbecue Bob's. Caitlin and R.O.A.R. break Carter Sweeney out of prison. The Sweeneys kidnap Mark from his home. They ask Mark to figure out a way to obtain $100 million or they will keep blowing up stores and restaurants, killing innocent people. Mark agrees and comes up with an ingenious plan that works, involving a fake armored car.

With help from the groom, a bride plots the murder of her wealthy father, planning to frame her arrogant stepmother for the crime.

A supposedly dead man escapes from the pathology lab and terrorizes Community General. However during their search for the man, they learn some dark secrets.

A mystery novelist murders her agent, hoping the investigation into his murder will inspire her next book. Guest Stars: Shelley Long, Adam West and Richard Herd

After Amanda reports seeing a murder on the Internet, a hacker messes up all her online transactions. Three hacker friends of Jesse fight back, using The Weasel. Hence ensues the battle of the hackers.

Steve joins his troubled partner, Reggie Ackroyd (Joe Penny) in a rehab facility for stressed-out cops. Reggie seems delusional and keeps blaming a murderer he caught for abducting his wife and daughter, and Steve encourages him. He and Steve are released and go hunting for them, and find their bodies by following the voices in Reggie's head. But Diagnosis Murder has not gone superstitious; there is a perfectly rational explanation at the end.

Jesse and Susan get stuck in a small coastal town with car trouble, on their way to Carmel for a romantic getaway. Susan spots her fiancė, Greg (Laurence Lau), who supposedly died 5 years ago. The town seems very affluent without any apparent source of wealth. When Greg is murdered, Jesse and Susan are charged with the crime by Sheriff Kelso (Monte Markham), in an attempt to cover up the town's dirty secret.

Steve goes undercover to investigate a series of murders at an exclusive gated community. He is "helped" by a tabloid reporter posing as his wife. Several of the live residents are listed as dead by fingerprint records.

A retiring detective Harry Trumble (Jack Klugman) continues to pursue a murderer known as "The Clown Killer", and will lie, cheat and kill to do it.

An accident victim develops a fatal attraction to Jesse.

A heavily armed criminal seems to have a death wish, and Mark tries to figure out why and why he's after Steve.

A juvenile delinquent, Tommy Anders (Shane Van Dyke), is assigned community-service time at a boxing gym, where the death of a young fighter arouses suspicion. He ran in front of a bus to show that he was invincible. (If some of the other delinquents at the gym resemble Tommy, it's no accident, because there are other Van Dyke kids there.) Something in the bottled drinks is making the young boxers very pugnacious.

An unusual patient in Community general is the "Masked Magician", who reveals magic tricks in highly rated specials on Pox TV, but got wounded by a real arrow because of sabotage. Meanwhile rival channel GBC prepares a series "Doctor Danger", supposedly based on Mark Sloan, but when shown the pilot he refuses to have anything to do with this mockery; Jesse however accepts to write scripts for it. Shortly after, both the masked magician -who unveiled himself to become irreplaceable- and Mark's character 'Dr. Danger' are murdered on the set. Mark tricks the first killer, but accepts that motive doesn't hold true for the first, so a second murderer must still be out. While Kent Beudine presents a cynical show on the horror gripping Hollywood after two TV celebrity murders, Marc is convinced Jesse is on the right track for motive by remarking it all upsets the program line-ups of rivaling networks in terms of the almighty ratings. Producer Jackson Burley is ignored even by his former protégés, and minutes after star Jerry Lane turns down an offer to transfer to West Coast VP Garth Zand's network GBS, the winner on Thursday after the previous crimes, he is run over by a fake parking valet. After Zand invites Marc for a scary gourmet dinner, featuring the potentially fatal Japanese blowfish, his luck changes: he finds himself in Community General and all GBS executives refuse his calls, after Lane exposes him he literally fears for a killer and switches his patient file with his roommate's.

Mark Sloan attempts to have a new doctor arrested for murder after she helps a pair of terminally ill patients commit suicide. Guest Star: Kim Little (plays Nurse Susan Hilliard), and Arthur Rosenberg (plays Harold Lomax, in his first appearance he is played by Richard Fancy and is the Administrator at Community General Hospital).