The period of the first independent Latvia State

Originally the school with 49 children started its work as the State Pārdaugava Secondary School directed by its first principal Pēteris Aivars (Ļūļaks) on 19 September 1921 and at that time used the premises of the Primary School No.16 and the City Library No. 2 at the corner of Dārtas and Zeļļu streets (presently, the location of the Primary School named after Fricis Brīvzemnieks).

In the following year the school was renamed the Riga State Secondary School No. 2, to be renamed again in 1931 as the Riga State Gymnasium No. 2. In the spring 1930, the foundation stone was laid for the new building of the school at Agenskala Priedes – a district in Pārdaugava, and on 5 December 1931 the new school building was opened (architect – Indriķis Blankenburgs). On 7 May 1938, the school flag was officially adopted and blessed and the date was marked as School Flag Day.

The time under the Soviet regime

After the Soviet occupation of Latvia, on 15 September 1940 the name of the school was changed to the Riga Secondary School No. 5. During the German occupation, in 1942 the school got back its former name, yet the premises of the school were used by the military hospital and the lessons had to take place in other locations and were not regular. After the second Soviet occupation of Latvia by the Red Army the German military hospital was liquidated and on 13 November 1944 the school resumed its work as the Riga Secondary School No. 5. In February 1946, the school premises were shared with a children's music school (nowadays – Pavuls Jurjans Music School). Since 1956, after its merging with the Primary School No. 46, the school offered education from class 1 to 11. In 1957, the school was named after Zenta Ozola – a graduate of the school of 1941. In 1962, the school started its indepth specialisation in German. In 1982, for establishing and developing friendly ties between the GDR and the USSR, the school was awarded “The Golden Needle” GDR badge of honour.

The time after the restoration of the independent Latvia State

After the restoration of independence in 1991, the Riga Secondary School No. 5 named after Zenta Ozola was renamed the Agenskalns Gymnasium. In October 1991, when it celebrated its 70th anniversary, teacher Emīlija Palkavniece returned to the school the historical flag of the Riga State Gymnasium No. 2, which she had secretly kept for 45 years. In 1994, the Āgenskalns Primary School (class 1 to 6) was separated from the Āgenskalns Gymnasium and started its work at 4k-1 Kandavas street. Children from class 7 to 12 continued their education at the Āgenskalns Gymnasium. In 1997, the Āgenskalns Gymnasium became an examination centre for acquiring the German language 2nd degree proficiency diploma (DSD II) in Latvia. On 1 September 2001, a new annex of the school and the sport complex were opened. This project was realized by architect Andrejs Ģelzis – a school graduate of 1972. On 18 May 2004, the School History Museum was opened. Since 2007, the students who have contributed to the prestige of the school are awarded the Owl Prize (“Pūce”) initiated by Jānis Vasariņš – also a graduate of the school. On 1 November 2010, the school regained the status of a state grammar school with the name of the Riga State German Grammar School. In 2013, the school fountain was opened. In 2016, the school celebrated its 95th anniversary since its establishment and the 85th anniversary since the opening of the main school building.