Roundup Ready is the Monsanto trademark for its patented line of genetically modified crop seeds that are resistant to its glyphosate-based herbicide, Roundup.

History

In 1996, genetically modified Roundup Ready soybeans resistant to Roundup became commercially available, followed by Roundup Ready corn in 1998.[1] Current Roundup Ready crops include soy, corn (maize), canola,[2] sugar beets,[3] cotton, and alfalfa,[4] with wheat[5] still under development. Additional information on Roundup Ready crops is available on the GM Crops List.[6] As of 2005, 87% of U.S. soybean fields were planted with glyphosate resistant varieties.[7][8]

While the use of Roundup Ready crops has increased the usage of herbicides measured in pounds applied per acre,[9] it has also changed the herbicide use profile away from atrazine, metribuzin, and alachlor which are more likely to be present in run off water.

An injunction in the case of Center for Food Safety v. USDA in September, 2010 prevented farmers from planting Roundup Ready sugar beets across the United States until a remedial environmental impact report could be filed, prompting some fear of a sugar shortage.[10] The USDA completed an environmental impact study of Roundup Ready sugar beets in 2012 and concluded that they are safe, at which time they were deregulated.[11]

In 2016, Monsanto introduced Roundup Ready Xtend soybeans, modified to tolerate both dicamba and glyphosate. Xtend soybeans were planted on 1 million acres in 2016, and by 2020 were projected to be planted on 50 million acres.[12]

Patents

The US patent for Roundup Ready soybeans expired in 2014.[13] The US patent for Roundup Ready canola expired on 26 April 2022.[14] The 2022 film Percy is based on Canadian farmer Percy Schmeiser's legal battle against Monsanto over the Roundup Ready canola patent.[14]

Genetic engineering

Some microorganisms have a version of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS: EC 2.5.1.19, 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthetase; phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase) that is resistant to glyphosate inhibition. The version used in genetically modified crops was isolated from Agrobacterium strain CP4 (CP4 EPSPS) that was resistant to glyphosate.[15][16] The CP4 EPSPS gene was cloned and inserted into soybeans. The CP4 EPSPS gene was engineered for plant expression by fusing the 5' end of the gene to a chloroplast transit peptide derived from the petunia EPSPS. This transit peptide was used because it had shown previously an ability to deliver bacterial EPSPS to the chloroplasts of other plants. The plasmid used to move the gene into soybeans was PV-GMGTO4. It contained three bacterial genes, two CP4 EPSPS genes, and a gene encoding beta-glucuronidase (GUS) from Escherichia coli as a marker. The DNA was injected into the soybeans using the particle-acceleration method or "gene gun". Soybean cultivar A54O3 was used for the transformation. The expression of the GUS gene was used as the initial evidence of transformation. GUS expression was detected by a staining method in which the GUS enzyme converts a substrate into a blue precipitate. Those plants that showed GUS expression were then taken and sprayed with glyphosate and their tolerance was tested over many generations.

Productivity claims

Under special conditions meant to reveal only genetic yield factors, RR lines actually have worse yields. In 1999, a review of Roundup Ready soybean crops found that, compared to the top conventional varieties, they had a 6.7% lower yield.[9] This so called "yield drag" follows the same pattern observed when other traits are introduced into soybeans by conventional breeding.[17] Monsanto claims later patented varieties yield 7-11% higher than their poorly performing initial varieties, closer to those of conventional farming, although the company refrains from citing actual yields.[18] Monsanto's 2006 application to USDA states that RR2 (mon89788) yields 1.6 bu less than A3244, the conventional variety that the trait is inserted into.[19]

Many genetically engineered crops have similar yield alterations due to one or both of the common causes for this. Roundup Ready crops have both: Yield drag due to the modification itself interfering with yield production; and yield lag due to the delay in breeding the best new yield genetics into the RR lines.[20]

Because this kind of testing is done under artificial conditions, these results do not hold for actual field conditions with weed pressure.[20] Under realistic field use the weed control advantages are more significant.

References

  1. ↑ "Monsanto Company History". Monsanto.com. 2008-11-03. Archived from the original on 2008-04-23. Retrieved 2010-08-22.
  2. ↑ "Monsanto Genuity Roundup Ready canola trait". Genuity.com. 2008-11-03. Retrieved 2010-08-22.
  3. ↑ "Monsanto Genuity Roundup Ready sugarbeets trait". Genuity.com. 2008-11-03. Retrieved 2010-08-22.
  4. ↑ ISSAA GM database approval entry for alfalfa event MON-00101
  5. ↑ ISAAA GM approval database entry for wheat event MON71800
  6. ↑ International Service for the Acquisition of Agri-Biotech Applications - GM Crop List
  7. ↑ USDA/APHIS Environmental Assessment — In response to Monsanto Petition 06-178-01p seeking a Determination of Non-regulated Status for Roundup Ready 2 Yield Soybean MON 89788, OECD Unique Identifier MON-89788-1, U.S. Department of Agriculture Animal and Plant Health Inspection Service + Biotechnology Regulatory Services page 13
  8. ↑ National Agriculture Statistics Service (2005) in Acreage eds. Johanns, M. & Wiyatt, S. D. 6 30, (U.S. Dept. of Agriculture, Washington, DC).
  9. 1 2 Charles Benbrook. Evidence of the Magnitude and Consequences of the Roundup Ready Soybean Yield Drag from University-Based Varietal Trials in 1998. Ag BioTech InfoNet Technical Paper Number 1
  10. ↑ "Sugar Beet Beatdown: Engineered Varieties Banned". NPR.org.
  11. ↑ "USDA APHIS | USDA Announces Final Environmental Impact Statement and Plant Pest Risk Assessment for Genetically Engineered Sugar Beets". Archived from the original on 2020-06-12. Retrieved 2020-06-12.
  12. ↑ Polansek, Tom; Nickel, Rod (4 March 2020). "Bayer's top seed faces U.S. soybean challenge from Corteva". Reuters. Retrieved 19 August 2020.
  13. ↑ "Monsanto Will Let Bio-Crop Patents Expire". Business Week. January 21, 2010. Archived from the original on January 27, 2010. Retrieved 25 January 2010.
  14. 1 2 Pratt, Sean (14 October 2021). "Roundup Ready canola patent set to expire". The Western Producer. Retrieved 26 November 2021.
  15. ↑ Development and Characterization of a CP4 EPSPS-Based, Glyphosate-Tolerant Corn Event,G. R. Heck et al. Crop Sci. 45:329-339 (2005). Archived 2009-03-19 at the Wayback Machine
  16. ↑ Molecular basis for the herbicide resistance of Roundup Ready crops, T. Funke et al., PNAS 2006 103:13010-13015
  17. ↑ Caviness, Charles E.; Walters, H.J. (1971). "Effect of phytophthora rot on yield and chemical composition of soybean seed". Crop Science. Madison, Wisconsin: ACSESS. 11 (1): 83–84. doi:10.2135/cropsci1971.0011183X001100010029x.
  18. ↑ "Roundup Ready 2 Yield® Soybeans | Bayer Traits". Bayer CropScience.
  19. ↑ "Microsoft Word - RR2Y USDA Revised 11.03.06a.doc" (PDF). Retrieved August 22, 2010.
  20. 1 2 Gurian-Sherman, Douglas (April 2009). Failure To Yield - Evaluating the Performance of Genetically Engineered Crops (PDF). Union of Concerned Scientists. S2CID 6332194.

See also

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