Rufino may refer to:
- Rufino (given name)
- Rufino Family, Filipino family
- Rufinus of Assisi, Italian saint sometimes known as Rufino
- Rufino, Santa Fe, Argentina
- Rufino Plaza, Tallest skyscraper in the Philippines
See also
- Ruffino, a wine producer based in the Tuscany region of Italy
- Rufinus (disambiguation)
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