S100A8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS100A8, 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100 calcium binding protein A8, S100-A8
External IDsOMIM: 123885 MGI: 88244 HomoloGene: 2225 GeneCards: S100A8
Orthologs
SpeciesHumanMouse
Entrez

6279

20201

Ensembl

ENSG00000143546

ENSMUSG00000056054

UniProt

P05109

P27005

RefSeq (mRNA)

NM_002964
NM_001319196
NM_001319197
NM_001319198
NM_001319201

NM_013650

RefSeq (protein)

NP_001306125
NP_001306126
NP_001306127
NP_001306130
NP_002955

NP_038678

Location (UCSC)Chr 1: 153.39 – 153.39 MbChr 3: 90.58 – 90.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene.[5] It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis [5] and post COVID-19 condition.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143546 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056054 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: S100A8 S100 calcium binding protein A8".
  6. Ryan FJ, Hope CM, Masavuli MG, Lynn MA, Mekonnen ZA, Yeow AE, et al. (January 2022). "Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection". BMC Medicine. 20 (1): 26. doi:10.1186/s12916-021-02228-6. PMC 8758383. PMID 35027067.

Further reading

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