SMO or Smo may refer to:
Biology
- Smoothened, a gene that encodes a protein of the same name
- Spermine oxidase, an enzyme
- Styrene monooxygenase, an enzyme
Computing and technology
- Sequential minimal optimization, an algorithm for training support vector machines
- Social media optimization
- Solar Monitoring Observatory, on the International Space Station
- SQL Server Management Objects for Microsoft SQL Server
Organizations
- Sabhal Mòr Ostaig, a Scottish Gaelic-medium public college on the Isle of Skye
- Slovak Youth Orchestra
Transport
- SMO, IATA airport code for Santa Monica Airport, USA
- SMO, National Rail station code for South Merton railway station, London
Other uses
- SMO, ITU country code for Samoa
- smo, ISO 639-3 code for the Samoan language
- Smo, former stage name of Sara Forsberg (born 1994), Finnish singer
- SMO, a character first appeared in the episode "Be More" of the animated series Adventure Time
- Senior Medical Officer, a rank in the British Royal Army Medical Corps
- Singapore Mathematical Olympiad, a mathematics competition
- Site management organization, a provider of services to an organization holding a clinical trial
- Social movement organization, a formal organization within a social movement
- Special military operation, the Russian government's name for the 2022 Invasion of Ukraine
- Super Mario Odyssey, a video game released for the Nintendo Switch
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