SPIS may refer to:
- Second Philippine International School, a Philippine international school in Riyadh, Saudi Arabia
- Scottish Police Information Strategy, former name of the Scottish Police Services Authority – Information Communications Technology
- (Senate) Preparedness Investigating Subcommittee of the United States Senate, involved in the Fulbright Hearings
- Pias Airport (ICAO code), Pias, Peru
- Spiš, a region in north-eastern Slovakia, with a very small area in south-eastern Poland
- Spiš Castle, one of the largest castle sites in Central Europe
- Spiš county, an administrative county of the Kingdom of Hungary
See also
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