SSRI is an acronym that stands for several things, including:

• the class of antidepressants called selective serotonin reuptake inhibitor. (Cf. Reuptake enhancer)
• the stock symbol for Silver Standard Resources Inc.
• Social Security Retirement Income in the United States
• Soviet Socialist Republic of Iran, aka the Persian Socialist Soviet Republic
• the Steinhardt Social Research Institute at Brandeis University
• the acronym of the Soviet Union in Uzbek (Sovet Sotsialistik Respublikalari Ittifoqi)