Safo may refer to:
- Balcha Safo (1863–1936), Ethiopian general
- Lucy Safo, Ghanaian writer
- Safo, Mali, a town and commune in the Koulikoro Region of Mali
- Safo, Niger, a village and rural commune in Niger
- Safo, historia de una pasión, a 1943 Argentine romantic drama film
- Sarah Adwoa Safo, a Ghanaian lawyer and politician
- Safo'63, ("Love and Sex (Sappho '63)"), a 1964 Mexican film
See also
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