St. Anthony's fire (also known historically as Ignis Sacer and Holy Fire) may refer to:
- Ergotism, the effect of long-term ergot poisoning, traditionally due to the ingestion of alkaloids
- Erysipelas, an acute infection, typically with a skin rash
- St Anthony's Fire (novel), a 1994 Doctor Who novel by Mark Gatiss
- Shingles, a painful viral disease, also called herpes zoster
See also
- Saint Anthony (disambiguation)
- St. Elmo's fire, a weather phenomenon
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