Sandra Smith may refer to:
- Sandra L. Smith, former leader of the Communist Party of Canada (Marxist-Leninist)
- Sandra Dorne (1924–1992), née Smith, actress
- Sandra Smith (actress), retired American actress
- Sandra Smith (criminal) (1965–1989), South African woman sentenced to death for murder, the last woman to be executed in the country
- Sandra Smith (reporter) (born 1980), reporter for the Fox Business Network in New York City
- Sandra Smith (cyclist) (born 1968), Australian Paralympian
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