Santiago López may refer to:
- Santiago López de Medrano (born 1942), Mexican mathematician
- Santiago López de Rego y Labarta (1869–1941), Spanish clergyman
- Santiago López Valdivielso (1950–2024), Spanish politician and businessman
- Santiago López (footballer, born 1982), Uruguayan forward
- Santiago López (footballer, born 1989), Argentine midfielder
- Santiago López (footballer, born 1991), Uruguayan midfielder
- Santiago López (footballer, born 1992), Mexican midfielder
- Santiago López (footballer, born August 1997), Argentine defender
- Santiago López (footballer, born December 1997), Argentine midfielder
- Santiago López (footballer, born 2006), Argentine midfielder
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