Santini is an Italian surname. Notable people with the surname include:
- André Santini (born 1940), French politician
- Bob Santini (born 1932), American former professional basketball player
- Brandon Santini (born 1982), American blues harmonica player, singer and songwriter
- Chay Santini, Puerto Rican fashion model and actress
- Claudio Santini (born 1992), Italian football player
- Dalmazio Santini (1923 - 2001), Italian-born U.S. composer
- Daniele Santini (born 1992), Italian sprint canoeist.
- Didier Santini (born 1968), retired French professional football player
- Edna Santini (born 1992), Brazilian rugby sevens player
- Fortunato Santini (1777-1861), Italian priest, composer and music collector
- Gabriel Santini (born 2000), Italian footballer
- Gabriele Santini (1886-1964), Italian conductor
- Giovanni Sante Gaspero Santini (1787-1877), Italian astronomer and mathematician
- Graziella Santini (born 1960), Sammarinese athlete
- Giuseppe Santini (1735-1796), Italian abbot and a mathematician
- Inti Muñoz Santini (born 1974), Mexican politician
- Ivan Santini (born 1989), Croatian footballer
- Jacques Santini, French footballer
- James David Santini (1937-2015), United States Representative from Nevada
- Jan Santini Aichel (1677-1723), Czech baroque architect of Italian descent
- Jorge Santini, Puerto Rican politician, former mayor of San Juan
- Krševan Santini (born 1987), Croatian football goalkeeper
- Nadia Santini, Italian chef
- Nilmaris Santini (1959-2006), Puerto Rican female judoka
- Norma Santini (born 1932), Venezuelan fencer
- Rinaldo Santini (1914-2013), Italian Christian Democrat politician
- Ruggiero Santini (1870-1958), Italian general
- Steven Santini (born 1995), American ice hockey defenseman
- Seven Santini Brothers, founders of the eponymous moving and storage company
- Wellentony Tafua Santini (born 1993), Australian rugby league footballer
Fictional characters
- Dominic Santini, a character in the television series Airwolf
- Carla Santini, a character in the film/book Confessions of a Teenage Drama Queen
See also
- 37699 Santini-Aichl, a minor planet discovered
- 4158 Santini, a minor planet
- Santini SMS, Italian cycling clothes brand
- Santini-Conti, professional continental cycling team registered in Italy
- Seven Santini Brothers, full-service American moving, storage, and relocation company
- The Great Santini (novel), written by Pat Conroy and published in 1976
- Santino, a male given name
- Santos (disambiguation)
- Satini, a given name and surname
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