Sassetti is a surname. Notable people with the surname include:
- Andrea Sassetti (born 1960), Italian shoe designer, owner of the Italian fashion company Andrea Moda
- Bernardo Sassetti (born 1970), Portuguese jazz pianist and film composer
- Filippo Sassetti, (1540–1588) Italian merchant
- Francesco Sassetti (1421–1490), Italian banker
- João Sassetti (1892–1946), Portuguese fencer
See also
- Sassetti Chapel, a chapel in the basilica of Santa Trinita, Florence, Italy
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