Sempill or Semple may refer to:
People
- Francis Sempill (1616?–1682), Scottish writer, son of Robert the younger
 - James Sempill (1566–1626), Scottish courtier and diplomat
 - Hugh Sempill (1596–1654), Scottish mathematician
 - Robert Sempill (c.1530–1595), Scottish balladeer
 - Robert Sempill the younger (1595?–1663?), Scottish writer, son of Robert
 - William Forbes-Sempill, 19th Lord Sempill (1893–1965), Scottish pioneering aviator and Japanese spy
 
Other uses
- Clan Sempill, a Lowland Scottish clan
 - Lord Sempill, a title in the Peerage of Scotland
 - Sempill Mission, a 1921 military mission to Japan
 
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