Senator Hughes may refer to:

United States Senate members

• Charles J. Hughes Jr. (1853–1911), U.S. Senator from Colorado from 1909 to 1911
• Harold Hughes (1922–1996), U.S. Senator from Iowa from 1969 until 1975
• James H. Hughes (1867–1953), U.S. Senator from Delaware from 1937 to 1943
• William Hughes (U.S. senator) (1872–1918), U.S. Senator from New Jersey from 1913 to 1918

United States state senate members

• Bryan Hughes (politician) (born 1969), Texas State Senate
• Charles Hughes (representative) (1822–1887), New York State Senate
• Dan Hughes (Nebraska politician) (born 1956), Nebraska State Senate
• Dudley Mays Hughes (1848–1927), Georgia State Senate
• Edward J. Hughes Jr. (fl. 1970s), New Jersey State Senate
• Edward J. Hughes (1888–1944), Illinois State Senate
• Francis Wade Hughes (1817–1885), Pennsylvania State Senate
• Harry Hughes (1926–2019), Maryland State Senate
• Henry Hughes (sociologist) (1829–1862), Mississippi State Senate
• James A. Hughes (1861–1930), West Virginia State Senate
• Jerome M. Hughes (1929–2015), Minnesota State Senate
• Jim Hughes (politician) (born 1964), Ohio State Senate
• John H. Hughes (politician) (1904–1972), New York State Senate
• Mildred Barry Hughes (1902–1995), New Jersey State Senate
• Ralph M. Hughes (born 1948), Maryland State Senate
• Shelley Hughes (born 1958), Alaska State Senate
• Teresa Patterson Hughes (1932–2011), California State Senate
• Vincent Hughes (born 1956), Pennsylvania State Senate