Separate Ways may refer to:

• Separate Ways (Elvis Presley album), 1973 compilation by Elvis Presley
  • "Separate Ways" (Elvis Presley song), title track of the above album
• Separate Ways, a 1981 film starring Karen Black
• "Separate Ways (Worlds Apart)", 1983 single by Journey
• "Separate Ways", 1992 single of the After Hours album by Gary Moore
• "Separate Ways" (Faye Wong song), title track of 2001 EP by Faye Wong
• "Separate Ways (Worlds Apart)", 2002 episode of Dawson's Creek
• Separate Ways (Teddy Thompson album), 2005 album by Teddy Thompson, or its title track
• Separate Ways (novel), novel by Ichiyō Higuchi
• Separate Ways, a bonus campaign from the 2005 video game Resident Evil 4 and its 2023 remake.