Night terror
Other namesSleep terror, pavor nocturnus
SpecialtyPsychiatry, Sleep medicine, Clinical Psychology
Symptomsfeelings of panic or dread, sudden motor activity, thrashing, sweating, rapid breathing, increased heart rate
Usual onsetearly childhood; symptoms tend to decrease with age
Duration1 to 10 minutes
Differential diagnosisepileptic seizure, nightmares

Night terror, also called sleep terror, is a sleep disorder causing feelings of panic or dread and typically occurring during the first hours of stage 3–4 non-rapid eye movement (NREM) sleep[1] and lasting for 1 to 10 minutes.[2] It can last longer, especially in children.[2] Sleep terror is classified in the category of NREM-related parasomnias in the International Classification of Sleep Disorders.[3] There are two other categories: REM-related parasomnias and other parasomnias.[3] Parasomnias are qualified as undesirable physical events or experiences that occur during entry into sleep, during sleep, or during arousal from sleep.[4]

Sleep terrors usually begin in childhood and usually decrease as age increases.[2] Factors that may lead to sleep terrors are young age, sleep deprivation, medications, stress, fever, and intrinsic sleep disorders.[5] The frequency and severity differ among individuals; the interval between episodes can be as long as weeks and as short as minutes or hours.[6] This has created a situation in which any type of nocturnal attack or nightmare may be confused with and reported as a night terror.[7]

Night terrors tend to happen during periods of arousal from delta sleep, or slow-wave sleep.[8][7] Delta sleep occurs most often during the first half of a sleep cycle, which indicates that people with more delta-sleep activity are more prone to night terrors. However, they can also occur during daytime naps.[6] Night terrors can often be mistaken for confusional arousal.[8]

While nightmares (bad dreams during REM sleep that cause feelings of horror or fear) are relatively common during childhood, night terrors occur less frequently.[9] The prevalence of sleep terrors in general is unknown.[2] The number of small children who experience sleep terror episodes (distinct from sleep terror disorder, which is recurrent and causes distress or impairment[2]) are estimated at 36.9% at 18 months of age and at 19.7% at 30 months.[2] In adults, the prevalence is lower, at only 2.2%.[2] Night terrors have been known since ancient times, although it was impossible to differentiate them from nightmares until rapid eye movement was studied.[7]

Signs and symptoms

Frans Verhas, Inconsolable, 1878 (Royal Museum of Fine Arts Antwerp)

The universal feature of night terrors is inconsolability, very similar to that of a panic attack.[10] During night terror bouts, people are usually described as "bolting upright" with their eyes wide open and a look of fear and panic on their faces. They will often yell, scream, or attempt to speak, though such speech is often incomprehensible. Furthermore, they will usually sweat, exhibit rapid breathing, and have a rapid heart rate (autonomic signs). In some cases, individuals are likely to have even more elaborate motor activity, such as a thrashing of limbs—which may include punching, swinging, or fleeing motions. There is a sense that the individuals are trying to protect themselves and/or escape from a possible threat of bodily injury.[6] Although people may seem to be awake during a night terror, they will appear confused, be inconsolable and/or unresponsive to attempts to communicate with them, and may not recognize others familiar to them. Occasionally, when a person with a night terror is awakened, they will lash out at the one awakening them, which can be dangerous to that individual. Most people who experience this do not remember the incident the next day,[8] although brief dream images or hallucinations may occur and be recalled.[4] Sleepwalking is also common during night-terror bouts,[7][11] as sleepwalking and night terrors are different manifestations of the same parasomnia.[7] Both children and adults may display behaviour indicative of attempting to escape; some may thrash about or get out of bed and begin walking or running around aimlessly while inconsolable, increasing the risk of accidental injury.[12] The risk of injury to others may be exacerbated by inadvertent provocation by nearby people, whose efforts to calm the individual may result in a physically violent response from the individual as they attempt to escape.[13]

During lab tests, subjects are known to have very high voltages of electroencephalography (EEG) delta activity, an increase in muscle tone, and a doubled or faster heart rate. Brain activities during a typical episode show theta and alpha activity when monitored with an EEG. Episodes can include tachycardia. Night terrors are also associated with intense autonomic discharge of tachypnea, flushing, diaphoresis, and mydriasis[10]—that is, unconscious or involuntary rapid breathing, reddening of the skin, profuse sweating, and dilation of the pupils. Abrupt but calmer arousal from NREM sleep, short of a full night-terror episode, is also common.

In children with night terrors, there is no increased occurrence of psychiatric diagnoses.[14] However, in adults with night terrors there is a close association with psychopathology and mental disorders. There may be an increased occurrence of night terrors—particularly among those with post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD). It is also likely that some personality disorders may occur in individuals with night terrors, such as dependent, schizoid, and borderline personality disorders.[14] There have been some symptoms of depression and anxiety that have increased in individuals that have frequent night terrors. Low blood sugar is associated with both pediatric and adult night terrors.[6][15] A study of adults with thalamic lesions of the brain and brainstem have been occasionally associated with night terrors.[16] Night terrors are closely linked to sleepwalking and frontal lobe epilepsy.[17]

Children

Night terrors typically occur in children between the ages of three and twelve years, with a peak onset in children aged three and a half years old.[18] An estimated 1–6% of children experience night terrors. Children of both sexes and all ethnic backgrounds are affected equally.[18] In children younger than three and a half years old, peak frequency of night terrors is at least one episode per week (up to 3–4 in rare cases). Among older children, peak frequency of night terrors is one or two episodes per month. The children will most likely have no recollection of the episode the next day. Pediatric evaluation may be sought to exclude the possibility that the night terrors are caused by seizure disorders or breathing problems.[18] Most children will outgrow sleep terrors.[19]

Adults

Night terrors in adults have been reported in all age ranges.[20] Though the symptoms of night terrors in adolescents and adults are similar, the cause, prognosis and treatment are qualitatively different. These night terrors can occur each night if the individual does not eat a proper diet, get the appropriate amount or quality of sleep (e.g. sleep apnea), is enduring stressful events, or if he or she remains untreated. Adult night terrors are much less common, and often respond to treatments to rectify causes of poor quality or quantity of sleep. Night terrors are classified as a mental and behavioral disorder in the ICD.[21] A study done about night terrors in adults showed that other psychiatric symptoms were prevalent in most patients experiencing night terrors hinting at the comorbidity of the two.[10] There is some evidence of a link between night terrors and hypoglycemia.[22]

When a night terror happens, it is typical for a person to wake up yelling and kicking and to be able to recognize what he or she is saying. The person may even run out of the house (more common among adults) which can then lead to violent actions.[23] It has been found that some adults who have been on a long-term intrathecal clonidine therapy show side effects of night terrors, such as feelings of terror early in the sleep cycle.[24] This is due to the possible alteration of cervical/brain clonidine concentration.[20] In adults, night terrors can be symptomatic of neurological disease and can be further investigated through an MRI procedure.[25]

Causes

There is some evidence that a predisposition to night terrors and other parasomnias may be congenital. Individuals frequently report that past family members have had either episodes of sleep terrors or sleepwalking. In some studies, a ten-fold increase in the prevalence of night terrors in first-degree biological relatives has been observed—however, the exact link to inheritance is not known.[6] Familial aggregation has been found suggesting that there is an autosomal mode of inheritance.[10] In addition, some laboratory findings suggest that sleep deprivation and having a fever can increase the likelihood of a night terror episode occurring.[26] Other contributing factors include nocturnal asthma, gastroesophageal reflux, central nervous system medications,[10] and a constricted nasal passage.[27] Special consideration must be used when the subject with narcolepsy, as there may be a link. There have been no findings that show a cultural difference between manifestations of night terrors, though it is thought that the significance and cause of night terrors differ within cultures.

Also, older children and adults provide highly detailed and descriptive images associated with their sleep terrors compared to younger children, who either cannot recall or only vaguely remember. Sleep terrors in children are also more likely to occur in males than females; in adults, the ratio between sexes is equal.[6] A longitudinal study examined twins, both identical and fraternal, and found that a significantly higher concordance rate of night terror was found in identical twins than in fraternal.[10][28]

Though the symptoms of night terrors in adolescents and adults are similar, their causes, prognoses, and treatments are qualitatively different. There is some evidence that suggests that night terrors can occur if the individual does not eat a proper diet, does not get the appropriate amount or quality of sleep (e.g., because of sleep apnea), or is enduring stressful events.[29] Adults who have experienced sexual abuse are more likely to receive a diagnosis of sleep disorders, including night terrors.[30] Overall, though, adult night terrors are much less common and often respond best to treatments that rectify causes of poor quality or quantity of sleep.

Diagnosis

The DSM-5 diagnostic criteria for sleep terror disorder requires:[2]

  • Recurrent periods where the individual abruptly but not completely wakes from sleep, usually occurring during the first third major period of sleep.
  • The individual experiences intense fear with a panicky scream at the beginning and symptoms of autonomic arousal, such as increased heart rate, heavy breathing, and increased perspiration. The individual cannot be soothed or comforted during the episode.
  • The individual is unable or almost unable to remember images of the dream (only a single visual scene for example).
  • The episode is completely forgotten.
  • The occurrence of the sleep terror episode causes clinically significant distress or impairment in the individual's functioning.
  • The disturbance is not due to the effects of a substance, general medical condition or medication.
  • Coexisting mental or medical disorders do not explain the episodes of sleep terrors.

Differential diagnosis

Night terrors are distinct from nightmares.[31] In fact, in nightmares there are almost never vocalization or agitation, and if there are any, they are less strong in comparison to night terrors.[31] In addition, nightmares appear ordinarily during REM sleep in contrast to night terrors, which occur in NREM sleep.[2] Finally, individuals with nightmares can wake up completely and easily and have clear and detailed memories of their dreams.[2][31]

A distinction between night terrors and epileptic seizure is required.[31] Indeed, an epileptic seizure could happen during the night but also during the day.[31] To make the difference between both of them, an EEG can be done and if there are some anomalies on it, it would rather be an epileptic seizure.[31]

Assessment

The assessment of sleep terrors is similar to the assessment of other parasomnias and must include:[32]

  • When the episode occurs during the sleep period
  • Age of onset
  • How often these episodes occur (frequency) and how long they last for (duration)
  • Description of the episode, including behavior, emotions, and thoughts during and after the event
  • How responsive the patient is to external stimuli during the episode
  • How conscious or aware the patient is, when awakened from an episode
  • If the episode is remembered afterwards
  • The triggers or precipitating factors
  • Sleep–wake pattern and sleep environment
  • Daytime sleepiness
  • Other sleep disorders that might be present
  • Family history for NREM parasomnias and other sleep disorders
  • Medical, psychiatric, and neurological history
  • Medication and substance use history

Additionally, a home video might be helpful for a proper diagnosis. A polysomnography in the sleep laboratory is recommended for ruling out other disorders, however, sleep terrors occur less frequently in the sleep laboratory than at home and a polysomnography can therefore be unsuccessful at recording the sleep terror episode.[32]

Treatment

In most children, night terrors eventually subside and do not need to be treated. It may be helpful to reassure the child and their family that they will outgrow this disorder.[33]

The duration of one episode is mostly brief but it may last longer if parents try to wake up the child.[34] Awakening the child may make their agitation stronger.[34] For all these reasons, it is important to let the sleep terror episode fade away and to just be vigilant in order for them not to fall to the ground.[34]

Considering an episode could be violent, it may be advisable to secure the environment in which the child sleeps. Windows should be closed and potentially dangerous items should be removed from the bedroom, and additionally, alarms can be installed and the child placed in a downstairs bedroom.[35]

There is some evidence to suggest that night terrors can result from lack of sleep or poor sleeping habits. In these cases, it can be helpful to improve the amount and quality of sleep which the child is getting.[33] It is also important to have a good sleep hygiene, if a child has night terrors parents could try to change their sleep hygiene.[34] Another option could be to adapt child's naps so that they are not too long or too short.[34] Then, excessive stress or conflicts in a child's life could also have an impact on their sleep too, so to have some strategies to cope with stress combined with psychotherapy could decrease the frequency of the episodes.[36] A polysomnography can be recommended if the child continues to have a lot of night terror episodes.[34]

Hypnosis could be efficient. Sleepers could become less sensitive to their sleep terrors.[35]

One technique is to wake up just before the sleep terrors begin. When they appear regularly, this method can prevent their appearance.[35]

Psychotherapy or counseling might be helpful in some cases.

If all these methods are not enough, benzodiazepines (such as diazepam) or tricyclic antidepressants may be used; however, medication is only recommended in extreme cases.[37] Widening the nasal airway by surgical removal of the adenoid was previously considered and demonstrated to be effective;[27] nowadays, however, invasive treatments are generally avoided.

Research

A small study of paroxetine found some benefit.[38]

Another small trial found benefit with L-5-hydroxytryptophan (L-5-HTP).[39]

See also

References

  1. ↑ Hockenbury, Don H. Hockenbury, Sandra E. (2010). Discovering psychology (5th ed.). New York: Worth Publishers. p. 157. ISBN 978-1-4292-1650-0.{{cite book}}: CS1 maint: multiple names: authors list (link)
  2. 1 2 3 4 5 6 7 8 9 10 American Psychiatric Association (May 22, 2013). Diagnostic and Statistical Manual of Mental Disorders (5th ed.). American Psychiatric Association. doi:10.1176/appi.books.9780890425596. ISBN 978-0890425558.
  3. 1 2 Sateia, Michael J. (November 2014). "International Classification of Sleep Disorders-Third Edition". Chest. 146 (5): 1387–1394. doi:10.1378/chest.14-0970. PMID 25367475.
  4. 1 2 Goldstein, Cathy A. (July 2011). "Parasomnias". Disease-a-Month. 57 (7): 364–388. doi:10.1016/j.disamonth.2011.04.007. PMID 21807161.
  5. ↑ Mason, T. B. A.; Pack, A. I. (2007). "Pediatric Parasomnias". Sleep. 30 (2): 141–151. doi:10.1093/sleep/30.2.141. PMID 17326539.
  6. 1 2 3 4 5 6 DSM-IV-TR: diagnostic and statistical manual of mental disorders (4th ed.). American Psychiatric Press. 2000. ISBN 978-0-89042-025-6.
  7. 1 2 3 4 5 Szelenberger, Waldemar; Niemcewicz, Szymon; Dąbrowska, Anna Justyna (2009). "Sleepwalking and night terrors: Psychopathological and psychophysiological correlates". International Review of Psychiatry. 17 (4): 263–70. doi:10.1080/09540260500104573. PMID 16194798. S2CID 28776384.
  8. 1 2 3 Bjorvatn, Bjørn; Grønli, Janne; Pallesen, Ståle (2010). "Prevalence of different parasomnias in the general population". Sleep Medicine. 11 (10): 1031–4. doi:10.1016/j.sleep.2010.07.011. PMID 21093361.
  9. ↑ "Facts for Families No. 34: Children's Sleep Problems". AACAP.org. American Academy of Child and Adolescent Psychiatry. Archived from the original on December 27, 2011. Retrieved December 20, 2011.
  10. 1 2 3 4 5 6 Nguyen, B. H.; Perusse, D.; Paquet, J.; Petit, D.; Boivin, M.; Tremblay, R. E.; Montplaisir, J. (2008). "Sleep Terrors in Children: A Prospective Study of Twins". Pediatrics. 122 (6): e1164–7. doi:10.1542/peds.2008-1303. PMID 19047218. S2CID 10386957.
  11. ↑ Oudiette, D.; Leu, S.; Pottier, M.; Buzare, M. A.; Brion, A.; Arnulf, I. (2009). "Dreamlike mentations during sleepwalking and sleep terrors in adults". Sleep. 32 (12): 1621–7. doi:10.1093/sleep/32.12.1621. PMC 2786046. PMID 20041598.
  12. ↑ "Sleep terrors (night terrors) - Symptoms and causes". Mayo Clinic. Retrieved 2020-02-27.
  13. ↑ "Violent behavior that occurs during disorders of arousal is provoked". American Academy of Sleep Medicine – Association for Sleep Clinicians and Researchers. 2007-08-01. Retrieved 2021-01-29.
  14. 1 2 "Night Terrors Follow-up – Prognosis". eMedicine.Medscape.com. Medscape Reference. Retrieved May 26, 2013.
  15. ↑ Blog from Fountia, "Things You Didn't Know About Night Terrors"
  16. ↑ Di Gennaro, Giancarlo; Autret, Alain; Mascia, Addolorata; Onorati, Paolo; Sebastiano, Fabio; Paolo Quarato, Pier (2004). "Night terrors associated with thalamic lesion". Clinical Neurophysiology. 115 (11): 2489–92. doi:10.1016/j.clinph.2004.05.029. PMID 15465436. S2CID 27573165.
  17. ↑ "Night Terrors - Pathophysiology". eMedicine.Medscape.com. Medscape Reference. Retrieved May 26, 2013.
  18. 1 2 3 Connelly, Kevin. "Night Terrors". WebMD. Retrieved July 20, 2011.
  19. ↑ Licht, Deborah (2016). Presenting Psychology. New York: Worth Publisher. p. 146. ISBN 9781319016371.
  20. 1 2 Bevacqua, Brian K.; Fattouh, Maher; Backonja, Misha (2007). "Depression, Night Terrors, and Insomnia Associated with Long-Term Intrathecal Clonidine Therapy". Pain Practice. 7 (1): 36–8. doi:10.1111/j.1533-2500.2007.00108.x. PMID 17305677. S2CID 37035801.
  21. ↑ "Mental and behavioural disorders".
  22. ↑ McMillan, Julia A. F. (2006). Oski's Pediatrics: Principles & Practice (4th ed.). Philadelphia: Lippincott Williams & Wilkins. p. 2353. ISBN 9780781738941.
  23. ↑ Kuhlmann, David. "Sleep Terrors". American Academy of Sleep Medicine. Archived from the original on October 16, 2014. Retrieved July 5, 2011.
  24. ↑ Snyder, David M.; Goodlin-Jones, Beth L.; Pionk, Mary Jane; Stein, Martin T. (2008). "Inconsolable Night-Time Awakening: Beyond Night Terrors". Journal of Developmental & Behavioral Pediatrics. 29 (4): 311–4. doi:10.1097/DBP.0b013e3181829f4c. PMID 18698194.
  25. ↑ Guzman, Carlos Simon; Wang, Yuan Pang (2008). "Sleep terror disorder: A case report". Revista Brasileira de Psiquiatria. 30 (2): 169. doi:10.1590/S1516-44462008000200016. PMID 18592111.
  26. ↑ American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders (4th (text revision) ed.). Washington DC.{{cite book}}: CS1 maint: location missing publisher (link)
  27. 1 2 Agrell, I.-G.; Axelsson, A. (1972). "The relationship between pavor nocturnus and adenoids". Acta Paedopsychiatrica. 39 (3): 46–53. PMID 4565015.
  28. ↑ Poblano, Adrián; Poblano-Alcalá, Adriana; Haro, Reyes (2010). "Sleep-terror in a child evolving into sleepwalking in adolescence: Case report with the patient's point of view". Revista Brasileira de Psiquiatria. 32 (3): 321–322. doi:10.1590/S1516-44462010000300022. PMID 20945027.
  29. ↑ Pritchard, Kiera (5 August 2020). "Night Terrors vs. Nightmares". Eachnight. Retrieved 15 November 2021.
  30. ↑ Chen, Laura P.; Murad, M. Hassan; Paras, Molly L.; Colbenson, Kristina M.; Sattler, Amelia L.; Goranson, Erin N.; Elamin, Mohamed B.; Seime, Richard J.; Shinozaki, Gen; Prokop, Larry J.; Zirakzadeh, Ali (2010). "Sexual Abuse and Lifetime Diagnosis of Psychiatric Disorders: Systematic Review and Meta-analysis". Mayo Clinic Proceedings. 85 (7): 618–29. doi:10.4065/mcp.2009.0583. PMC 2894717. PMID 20458101.
  31. 1 2 3 4 5 6 Organisation Mondiale de la Santé (1993). CIM 10–Classification Internationale des troubles Mentaux et des troubles du comportement: descriptions cliniques et directives pour le diagnostic. Paris.{{cite book}}: CS1 maint: location missing publisher (link)
  32. 1 2 Zadra, Antonio; Pilon, Mathieu (March 1, 2012). Parasomnias II. Oxford University Press. doi:10.1093/oxfordhb/9780195376203.013.0028.
  33. 1 2 Carter, K. A.; Hathaway, N. E.; Lettieri, C. F. (2014). "Common sleep disorders in children". American Family Physician. 89 (5): 368–77. PMID 24695508.
  34. 1 2 3 4 5 6 Pack, Allan I.; Mason, Thornton B. A. (September 1, 2005). "Sleep Terrors in Childhood". The Journal of Pediatrics. 147 (3): 388–392. doi:10.1016/j.jpeds.2005.06.042. ISSN 0022-3476. PMID 16182681.
  35. 1 2 3 Avidan, A. Y. (2017). "Non–rapid Eye Movement Parasomnias: Clinical Spectrum, Diagnostic Features, and Management". Principles and Practice of Sleep Medicine. Elsevier. pp. 981–992.
  36. ↑ Van Horn, N. L., & Street, M. (2019). Night Terrors. In StatPearls [Internet]. StatPearls Publishing.
  37. ↑ Fleetham, J. A.; Fleming, J. A. E. (2014). "Parasomnias". Canadian Medical Association Journal. 186 (8): E273–80. doi:10.1503/cmaj.120808. PMC 4016090. PMID 24799552.
  38. ↑ Wilson, S. J.; Lillywhite, A. R.; Potokar, J. P.; Bell, C. J.; Nutt, D. J. (1997). "Adult night terrors and paroxetine". Lancet. 350 (9072): 185. doi:10.1016/s0140-6736(05)62351-3. PMID 9250190. S2CID 40910299.
  39. ↑ Bruni, Oliviero; Ferri, Raffaele; Miano, Silvia; Verrillo, Elisabetta (2004). "L -5-Hydroxytryptophan treatment of sleep terrors in children". European Journal of Pediatrics. 163 (7): 402–7. doi:10.1007/s00431-004-1444-7. PMID 15146330. S2CID 8713465.
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