Smith Center may refer to:

• Smith Center, Kansas, a city in the United States
• Smith Center for the Performing Arts, in Las Vegas, Nevada, U.S.
• Smith Campus Center, a building at Harvard University in Cambridge, Massachusetts, U.S.
• Charles E. Smith Center, an arena at George Washington University in Washington D.C., U.S.
• Clarice Smith Performing Arts Center, at the University of Maryland, College Park, Maryland, U.S.
• Dean Smith Center, an arena at the University of North Carolina, Chapel Hill, North Carolina, U.S.