Soderini is an Italian surname and may refer to:
- House of Soderini, a noble Florentine family. To this family belong:
- Piero Soderini (1450 – 1522) Florentine statesman
- Francesco Soderini (1453–1524) Florentine diplomat and religious leader
- Paolo Antonio Soderini (1448 — after 1500) Florentine jurist
- Giovan Vettorio Soderini (1526–1596) Italian agronomist
- Eleonora degli Albizzi and Camilla Martelli were both mistresses of Grand Duke Cosimo I de' Medici and both were born to Soderini mothers. The latter married the Grand Duke.
See also
- Soderini letter, document describing a disputed early voyage by Amerigo Vespucci
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