In Marvel Comics, the Sorcerer Supreme is the primary protector of Earth against magical and mystical threats. The title may refer to one of the following fictional characters in Marvel Comics.

Earth-616

• Agamotto the All-Seeing, the very first Sorcerer Supreme and a member of the Avengers of 1,000,000 BC.
• Merlin, the court wizard of King Arthur and the Sorcerer Supreme of his era.
• Isaac Newton, a member of the Brotherhood of the Shield and the Sorcerer Supreme of his era.
• Kushala the Demon Rider, a skilled magic-wielder possessed by the Spirit of Vengeance, who becomes her era's Sorcerer Supreme.
• The Ancient One, the first Sorcerer Supreme introduced in the Marvel Universe, preceding Dr. Strange.
• Dr. Stephen Strange, the Ancient One's successor as the Sorcerer Supreme.
• Jericho Drumm, Dr. Strange's first successor as Sorcerer Supreme.
• Loki Laufeyson, Dr. Strange's second successor as Sorcerer Supreme.
• Clea Strange, Dr. Strange's wife and his third successor as Sorcerer Supreme, and the Sorceress Supreme of Earth X.
• William Kaplan, the Demiurge, who in the future of Earth-616 succeeds Dr. Strange as Sorcerer Supreme.

In other media

• Baron Karl Mordo, the Sorcerer Supreme in Mutant X, What If…?, and Earth-838 (in Doctor Strange in the Multiverse of Madness).
• Doc Magus, Dr. Strange's successor as Sorcerer Supreme in the MC2 universe.
• Sarah the Terrible Eye, who in a future of The Unbelievable Gwenpool succeeds Dr. Strange as Sorcerer Supreme.
• Ned Leeds, the Hobgoblin and protégé of Baron Mordo who rewrite reality to make himself Sorcerer Supreme in Symbiote Spider-Man.
• Shanzar, the Sorcerer Supreme of the Strange Matter Dimension, who turns the Hulk into Dark Hulk in The Incredible Hulk.
• Strange, a young woman who shares her body with a demon, and is the Sorceress Supreme of Earth of 2099: World of Tomorrow.
• Wong (portrayed by Benedict Wong), the Sorcerer Supreme succeeding the Ancient One in the Marvel Cinematic Universe.