Spagnoli is an Italian surname meaning "Spaniard", "Spanish" or "from Spain". Notable people with the name include:
- Giuseppe Spagnoli (1947–2003), Italian wrestler
- Jerry Spagnoli (born 1956), American daguerrotype photographer
- Luisa Spagnoli (1877-1935), Italian businesswoman
- Pietro Spagnoli (born 1964), Italian operatic baritone
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