Spanos is a surname of Greek origin. Notable people with the surname include:
- Alex Spanos (1923-2018), American owner of the San Diego Chargers
- Anthony Spanos (born 1995), Australian actor
- Danny Spanos, American musician
- Dean Spanos (born 1950), American president and CEO of the Los Angeles Chargers
- Giannis Spanos (1934-2019), Greek musician
- John Spanos (born 1961), Australian soccer player
- Lou Spanos (born 1971), American football coach
- Matt Spanos (born 1984), American football player
- Nicholas Spanos (1942-1994), American/Canadian psychology professor
- Peter Spanos (born 1948), American attorney at law
- Nick Spanos (died 1990), Australian murder victim
- Vasili Spanos (born 1981), American baseball player
- William V. Spanos (1924-2017), American literature
See also
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