"Speak to Me" is a song by Pink Floyd from the 1973 album The Dark Side of the Moon. The phrase may also refer to:

• "Speak to Me", a 1969 song by Jackie Lomax
• Speak to Me, a song by Audio Adrenaline from the 2001 album Lift
• Speak to Me, a 2007 album by Geoff Moore
• Speak to Me, a 2008 EP by Imagine Dragons
• "Speak to Me", a song by Roxette from the 2011 album Charm School
• "Speak to Me", a 2017 song by Amy Lee
• "Speak to Me", a song by Depeche Mode from the 2023 album Memento Mori